Institute of Biomedical Technologies

Drug release systems

PRINCIPAL INVESTIGATORS

Carmen María Évora García, PhD

Professor of Pharmaceutical Technology, Department of Clinical Engineering and Pharmaceutical Technology, ULL
Araceli Delgado Hernández, PhD

Professor of Pharmaceutical Technology, Department of Clinical Engineering and Pharmaceutical Technology, ULL

POSTDOCTORAL RESEARCHERS:

  • Edgar Pérez Herrero, PhD (Assistant Lecturer; Department of Chemical Engineering and Pharmaceutical Technology, ULL)
  • Ricardo Reyes Rodríguez, PhD (Assistant Lecturer, Department of Chemical Engineering and Pharmaceutical Technology, ULL)
  • Patricia Díaz Rodríguez, PhD (Assistant Lecturer, Department of Chemical Engineering and Pharmaceutical Technology, ULL)

PHD STUDENTS AND TRAINEES:

  • Patricia García García (PhD student)

RESEARCH LINES:

  • Systems of release for cartilage and bone regeneration, and for the resection of leiomyomas
  • Biodistribution of nanoparticle systems

FUNDED PROJECTS:

  • Injectable systems for bone regeneration in Osteoporosis (MAT2014-55657-R – “Sistemas inyectables para regeneración ósea en Osteoporosis”). PI: Carmen M. Évora. Ministry of Economy and Competitiveness, MINECO (2014-2018, extended until September 2019, 60,500 €)
  • Oligonucleotide-hybrid-nanosystems for local and systemic targeted therapies (RTI2018-097324-B-I00). PI: Carmen Évora, Araceli Delgado. Ministry of Science, Innovation and Universities (2019-2021, 181,500 €)
  • Preclinical development of a new drug for the treatment of hyperuricemia and hyperuremia (Exp. Matriz 19120187 – «Desarrollo preclínico de un nuevo fármaco para el tratamiento de la hiperuricemia e hiperuremia»). PIs: Araceli Delgado, Esteban Porrini. Arafarma Group S.A., FGULL (2019-2020, 199,870 €)

PUBLICATIONS 2019:

  • García-García P,Reyes R,Segredo-Morales E,Pérez-Herrero E,Delgado A,Évora C. PLGA-BMP-2 and PLA-17β-Estradiol Microspheres Reinforcing a Composite Hydrogel for Bone Regeneration in Osteoporosis. 2019 Dec 3;11(12). pii: E648. doi: 10.3390/pharmaceutics11120648
  • Goimil L, Santos-Rosales V, Delgado A, Évora C, Reyes R, Lozano-Pérez A, Aznar-Cervantes S, Cenis JL, Gómez-Amoza JL, Concheiro A, Alvarez-Lorenzo C, García-González CA. ScCO2-foamed silk fibroin aerogel/poly (ϵ-caprolactone) scaffolds containing dexamethasone for bone regeneration. Journal of CO2 2019; 31, pp. 51-64. doi: 10.1016/j.jcou.2019.02.016
  • Vayas R, Reyes R, Arnau MR, Évora C, Delgado A. Injectable Scaffold for Bone Marrow Stem Cells and Bone Morphogenetic Protein-2 to Repair Cartilage. Cartilage. 2019 Apr. doi: 10.1177/1947603519841682 [Epub ahead of print]
  • Pérez-Herrero E, García-García P, Gómez-Morales J, Llabrés M, Delgado A, Évora C. New injectable two-step forming hydrogel for delivery of bioactive substances in tissue regeneration. Regenerative Biomaterials. 2019 Jun;6(3):149-162. doi: 10.1093/rb/rbz018
  • García-García P, Ruiz M, Reyes R, Delgado A, Évora C, Riancho JA, Rodríguez-Rey JC, Pérez-Campo FM. Smurf1 Silencing Using a LNA-ASOs/Lipid Nanoparticle System to Promote Bone Regeneration. Stem Cells Transl Med. 2019 Dec;8(12):1306-1317. doi: 10.1002/sctm.19-0145
  • de Moraes Lenz T, Escanéz Pérez A, Tur R, Delgado A, Évora C, Almansa E. First attempts of the use of intake tracers in encapsulated diets with chitosan for octopus paralarvae. Aquaculture Research. 2019 Oct;50(10):3070-3073. doi: 10.1111/are.14234
  • Garcia-Orue I,Gainza G,Garcia-Garcia P,Gutierrez FB,Aguirre JJ,HernandezRM,Delgado A,Igartua M. Composite nanofibrous membranes of PLGA/Aloe vera containing lipid nanoparticles for wound dressing applications. Int J Pharm. 2019 Feb 10;556:320-329. doi: 10.1016/j.ijpharm.2018.12.010
  • Selected publications from the last 10 years:
  • Segredo-Morales E,Reyes R,Arnau MR,Delgado A,Évora C.In situ gel-forming system for dual BMP-2 and 17β-estradiol controlled release for bone regeneration in osteoporotic rats. Drug Deliv Transl Res. 2018 Oct;8(5):1103-1113. doi: 10.1007/s13346-018-0574-9
  • Del Rosario C, Rodriguez-Evora M, Reyes R, Évora C. BMP-2, PDGF-BB and bone marrow mesenchymal cells in a macroporous d-TCP scaffold for critical-size bone defect repair in rats. Biomed Mater. 2015 Jul 23;10(4):045008. doi: 10.1088/1748-6041/10/4/045008
  • Del Rosario C, Rodriguez-Evora M, Reyes R, Gonzalez-Orive A, Hernandez-Creus A, Shakesheff KM, White LJ, Delgado A, Évora C. Evaluation of nanostructure and microstructure of bone regenerated by BMP-2-porous scaffolds. J Biomed Mater Res A. 2015 Sep;103(9):2998-3011. doi: 10.1002/jbm.a.35436
  • Rodríguez-Evora M, Reyes R, Alvarez-Lorenzo C, Concheiro A, Delgado A, Evora C. Bone regeneration induced by an in situ gel-forming poloxamine, bone morphogenetic protein-2 system. J Biomed Nanotechnol. 2014 Jun;10(6):959-69. doi: 10.1166/jbn.2014.1801 Modelización matemática de sistemas biológicos y enfermedades humanas