Institute of Biomedical Technologies

PRINCIPAL INVESTIGATOR

Carlos Flores Infante, PhD

Contracted Investigator SCS/FIISC, Research Unit HUNSC and Genomic Unit of the Technological and Renewable Energies Institute

POSTDOCTORAL RESEARCHERS:

  • Itahisa Marcelino Rodríguez, PhD (Postdoctoral investigator, SCS/FIISC, Research Unit HUNSC)
  • Laura Ciuffreda, PhD (Postdoctoral investigator, SCS/FIISC, Research Unit HUNSC)

EXTERNAL POSTDOCTORAL COLLABORATORS:

  • Rafaela González Montelongo, PhD (Junior Researcher, Genomics Division of the Technological and Renewable Energies Institute)
  • Víctor García Olivares, PhD (Postdoctoral Researcher, Genomics Division of the Technological and Renewable Energies Institute)

PHD STUDENTS AND TRAINEES:

  • Beatriz Guillén Guío (The Canary Islands Agency of Research, Innovation and Information Sciences, ACIISI, The Canary Islands Government, TESIS2015010057, 2016-2019)
  • Natalia Hernández Pacheco (PFIS FI16/00136, ISCIII, 2017-2020)
  • Ana Díaz de Usera (FPU 16/01435, Ministry of Education, Culture and Sport, 2017-2020)
  • Tamara Hernández Beeftink (PFIS FI17/00177, ISCIII, 2018-2021)
  • Héctor Rodríguez Pérez (PFIS FI18/00230, ISCIII, 2019-2022)
  • Alejandro Mendoza Álvarez (CajaSiete ULL, 2018-2021)
  • Adrián Muñoz Barrera (Massive Genomics Data Analysis Service, CGIEU0000219140. Regional Goverment of Tenerife, Genomics Division of the Technological and Renewable Energies Institute)
  • Luis Alberto Rubio Rodríguez (Massive Genomics Data Analysis Service, CGIEU0000219140. Regional Goverment of Tenerife, Genomics Division of the Technological and Renewable Energies Institute)
  • David Jáspez Toledo (UDIGEN project, Spanish Ministry of Science, Innovation and Universities, RTC-2017-6471-1)
  • José M. Lorenzo-Salazar (Area coordinator, Genomics Division of the Technological and Renewable Energies Institute)

TECHNICAL AND ADMINISTRATIVE STAFF:

  • Almudena Corrales Moreno (Technician, SCS/FIISC, Research Unit HUNSC)
  • Antonio Íñigo Campos (Technician, Genomics Division of the Technological and Renewable Energies Institute)

RESEARCH LINES:

  • Genetics underlying the development and progression of prevalent (allergies, respiratory, infectious, immunological, etc.) and non-prevalent (mainly respiratory and immunological) diseases (“Genética involucrada en el desarrollo y progresión de enfermedades prevalentes (alérgicas, respiratorias, infecciosas, inmunológicas, etc.) y no prevalentes (principalmente respiratorias e inmunológicas”).
  • Population dynamics, evolution and disease in The Canary Islands (“Dinámica poblacional, evolución y enfermedad en Canarias”).
  • Biomarkers of prognosis in critically ill patients (methylome, transcriptome, microbiome, etc.) (“Biomarcadores de pronóstico en enfermos críticos (metiloma, transcriptoma, microbioma, etc.).
  • Clinical sequencing: development of bioinformatics tools and applications based on massive sequencing (“Secuenciación clínica, Desarrollo de herramientas bioinformáticas y aplicaciones basadas en secuenciación masiva”).

FUNDED PROJECTS:

  • Generation of a Genomic Diagnostic Unit (UDIGEN, RTC-2017-6471-1 – “Desarrollo de una Unidad de Diagnóstico Genómico”). PI: Carlos Flores. Ministry of Science, Innovation and Universities (2018-2021, 904,828.99 €).
  • Multiomics identification of genetic predictors of survival in sepsis patients (PI17/00610 – “Multiómica para la identificación de predictores genéticos de supervivencia en pacientes con sepsis”). PI: Carlos Flores. Institute of Health Carlos III (2018-2020, 99,220 €).
  • Pulmonary dysbiosis and early prognosis in patients with sepsis: towards a real- time assessment (PIFUN48/18). PI: Carlos Flores. The Canary Islands Health Research Institute Foundation (2019-2020, 21,863.50 €).
  • Genomic ancestry in human populations of the Canary Islands: African mixture, adaptation to the environment and health implications (2018PATRI20 – “Ascendencia genómica en las poblaciones humanas de Canarias: mezcla africana, adaptación al ambiente e implicaciones en salud”). PI: Carlos Flores. CajaCanarias Foundation (2019-2022, 29,475 €).
  • Facility for the Massive Analysis of Genomic Data (Tenerife Council, CGIEU0000219140). Contract: 2,700,000 € (2018-2022). PI: Carlos Flores Infante.

PUBLICATIONS 2019:

  • Hernandez-Pacheco N, Farzan N, Francis B, Karimi L, Repnik K, Vijverberg SJ, Soares P, Schieck M, Gorenjak M, Forno E, Eng C, Oh SS, Pérez-Méndez L, Berce V, Tavendale R, Samedy LA, Hunstman S, Hu D, Meade K, Farber HJ, Avila PC, Serebrisky D, Thyne SM, Brigino-Buenaventura E, Rodriguez-Cintron W, Sen S, Kumar R, Lenoir M, Rodriguez-Santana JR, Celedón JC, Mukhopadhyay S, Potočnik U, Pirmohamed M, Verhamme KM, Kabesch M, Palmer CNA, Hawcutt DB, Flores C, Maitland-van der Zee AH, Burchard EG, Pino-Yanes M. Genome-wide association study of inhaled corticosteroid response in admixed children with asthma. Clin Exp Allergy. 2019 Jun;49(6):789-798. doi: 10.1111/cea.13354
  • Hernandez-Pacheco N, Pino-Yanes M, Flores C. Genomic Predictors of Asthma Phenotypes and Treatment Response. Front Pediatr. 2019 Feb 5;7:6. doi: 10.3389/fped.2019.00006
  • Herrera-Luis E, Hernandez-Pacheco N, Vijverberg SJ, Flores C, Pino-Yanes M. Role of genomics in asthma exacerbations. 2019 Current Opinion in pulmonary Medicine 25(1), pp. 101-112. doi: 10.1097/MCP.0000000000000533
  • Rodríguez-Pérez H, Hernández-Beeftink, Lorenzo-Salazar JM, Roda-García JL, Pérez-González CJ, Colebrook M, Flores C. NanoDJ: a Dockerized Jupyter notebook for interactive Oxford Nanopore MinION sequence manipulation and genome assembly. BMC Bioinformatics. 2019 May 9;20(1):234. doi: 10.1186/s12859-019-2860-z
  • Perkins JR, Acosta-Herrera M, Plaza-Serón MC, Jurado-Escobar R, Doña I, García-Martín E, Isidoro-García M, Bartra J, Ribas-Perez D, Mayorga C, Torres MJ, Flores C, Cornejo-García JA. Polymorphisms in CEP68 gene associated with risk of immediate selective reactions to non-steroidal anti-inflammatory drugs. Pharmacogenomics J. 2019 Apr;19(2):191-199. doi: 10.1038/s41397-018-0038-0
  • Fregel R, Ordóñez AC, Santana-Cabrera J, Cabrera VM, Velasco-Vázquez J, Alberto V, Moreno-Benítez MA, Delgado-Darias T, Rodríguez-Rodríguez A, Hernández JC, Pais J, González-Montelongo R, Lorenzo-Salazar JM, Flores C, Cruz-de-Mercadal MC, Álvarez-Rodríguez N, Shapiro B, Arnay M, Bustamante CD. Mitogenomes illuminate the origin and migration patterns of the indigenous people of the Canary Islands. PLoS One. 2019 Mar 20;14(3):e0209125. doi: 10.1371/journal.pone.0209125
  • Mendoza-Alvarez A, Guillen-Guio B, Baez-Ortega A, Hernandez-Perez C, Lakhwani-Lakhwani S, Maeso MD, Lorenzo-Salazar JM, Morales M, Flores C. Whole-Exome Sequencing Identifies Somatic Mutations Associated With Mortality in Metastatic Clear Cell Kidney Carcinoma. Front Genet. 2019 May 15;10:439. doi: 10.3389/fgene.2019.00439
  • Espuela-Ortiz A, Lorenzo-Diaz F, Baez-Ortega A, Eng C, Hernandez-Pacheco N, Oh SS, Lenoir M, Burchard EG, Flores C, Pino-Yanes M. Bacterial salivary microbiome associates with asthma among african american children and young adults. Pediatr Pulmonol. 2019 Dec;54(12):1948-1956. doi: 10.1002/ppul.24504
  • Hernández-Beeftink T,Guillen-Guio B,Villar J,Flores C. Genomics and the acute respiratory distress syndrome: Current and future directions. Int J Mol Sci. 2019 Aug 16;20(16). pii: E4004. doi: 10.3390/ijms20164004
  • Marcelino-Rodriguez I,Callero A,Mendoza-Alvarez A,Perez-Rodriguez E,Barrios-Recio J,Garcia-Robaina JC, Flores C. Bradykinin-mediated angioedema: An update of the genetic causes and the impact of genomics. Front Genet. 2019 Sep 27;10:900. doi: 10.3389/fgene.2019.00900
  • Lorenzo-Salazar JM, Ma SF, Jou J, Hou PC, Guillen-Guio B, Allen RJ, Jenkins RG, Wain LV, Oldham JM, Noth I, Flores C. Novel idiopathic pulmonary fibrosis susceptibility variants revealed by deep sequencing (2019). European Respiratory Journal Open Research ERJ Open Res. 2019 Jun 10;5(2). pii: 00071-2019. doi: 10.1183/23120541.00071-2019
  • Serrano-Sánchez JA, Fernández-Rodríguez MJ, Sanchis-Moysi J, Rodríguez-Pérez MDC, Marcelino-Rodríguez I, Cabrera de León A. Domain and intensity of physical activity are associated with metabolic syndrome: A population-based study. PLoS One. 2019 Jul 17;14(7):e0219798. doi: 10.1371/journal.pone.0219798
  • Mate Redondo C, Rodríguez-Pérez MC, Domínguez Coello S, Pedrero García AJ, Marcelino Rodríguez I, Cuevas Fernández FJ, Almeida González D, Brito Díaz B, Rodríguez Esteban M, Cabrera de León A. Hospital Mortality in 415 798 AMI Patients: 4 Years Earlier in the Canary Islands Than in the Rest of Spain [Mortalidad hospitalaria de 415.798 pacientes con IAM: 4 años antes en Canarias que en el conjunto de España]. Rev Esp Cardiol (Engl Ed). 2019 Jun;72(6):466-472. doi:10.1016/j.rec.2018.06.023

OTHER SELECTED PUBLICATIONS FROM THE LAST 10 YEARS:

  • Botigué LR, Henn BM, Corona E, Gignoux CR, Gravel S, Atzmon G, Burns E, Ostrer H, Flores C, Bertranpetit J, Comas D, Bustamante CD. Gene flow from North Africa contributes to differential human genetic diversity in Southern Europe. Proc Natl Acad Sci USA. 2013 Jul 16;110(29):11791-6. doi: 10.1073/pnas.1306223110
  • Noth I, Zhang Y, Ma SF, Flores C, Barber M, Huang Y, Broderick SM, Wade M, Hysi P, Sciurba JD, Richards T, Juan-Guardela BM, Vij R, Han ML, Martinez FJ, Kossen K, Seiwert SD, Christie JD, Nicolae D, Kaminksi N, Garcia JGN. Genetic variants associated with idiopathic pulmonary fibrosis susceptibility and mortality: a genome-wide association study. Lancet Respiratory Medicine. 2013 Jun;1(4):309-317. doi: 10.1016/S2213-2600(13)70045-6
  • Baez-Ortega A, Lorenzo-Diaz F, Hernandez M, Gonzalez-Vila CI, Roda-Garcia JL, Colebrook M, Flores C. IonGAP: Integrative bacterial genome analysis for Ion Torrent sequence data. Bioinformatics. 2015 Sep 1;31(17):2870-3. doi: 10.1093/bioinformatics/btv283
  • Barreto-Luis A, Pino-Yanes M, Corrales A, Campo P, Callero A, Acosta-Herrera M, Cumplido J, Ma SF, Martinez-Tadeo J, Villar J, Garcia JGN, Carrillo T, Carracedo A, Blanca M, Flores C. Genome-wide association study in Spanish identifies ADAM metallopeptidase with thrombospondin type 1 motif, 9 (ADAMTS9), as a novel asthma susceptibility Journal of Allergy and Clinical Immunology. 2016Mar;137(3):964-6. doi: 10.1016/j.jaci.2015.09.051
  • Guillen-Guio B, Lorenzo-Salazar JM, González-Montelongo R, Díaz-de Usera A, Marcelino-Rodríguez I, Corrales A, Cabrera de León A, Alonso S, Flores C. Genomic analyses of human European diversity at the southwestern edge: isolation, African influence and disease associations in the Canary Islands. Molecular Biology and Evolution. Dec 1;35(12):3010-3026. doi: 10.1093/molbev/msy190