PRINCIPAL INVESTIGATOR

POSTDOCTORAL COLLABORATING RESEARCHERS:

• Luis Fabián Lorenzo Díaz, PhD (Assistant Lecturer; Department of Biochemistry, Microbiology, Cellular Biology and Genetics, ULL)

PHD STUDENTS AND TRAINEES:

• Natalia Hernández Pacheco (PhD student, contracted PFIS FI16/00136, Institute of Health Carlos III)
• Antonio Espuela Ortiz (PhD student; 2019_10, SAF201783417R, MINECO)
• Esther Herrera Luis (PhD student; FPI PRE2018-083837, Ministry of Science, Innovation and Universities, Project SAF2017-83417-R)
• Javier Pérez García (PhD student; 2019_34, Project SAF201783417R, MINECO)

RESEARCH LINES:

The Genomics and Health group aims to determine the genetic basis of asthma, focusing on acute complications and the response to available treatments. As such, and in addition to genome wide studies, we analyse genetic ancestry to perform admixture mapping and multiomic data integration. We also carry out asthma microbiome studies using massive sequencing techniques.

FUNDED PROJECTS:

• Search for genetic markers of asthma exacerbation: a genome-wide association study and respiratory micobiome analysis (SAF2017-83417-R “Búsqueda de marcadores genéticos relacionados con las exacerbaciones del asma: estudio de asociación genómico y análisis del microbioma respiratorio”). PIs: María del Mar del Pino Yanes and Fabián Lorenzo Díaz. Ministry of Economy, Industry and Competitiveness, MINECO (2018-2020, 171,094 €).
• SysPharmPediA: Systems pharmacology approach to difficult-to-treat paediatric asthma (AC15/00015). PI: María del Mar del Pino Yanes. Institute of Health Carlos III (20162019, 91.113 €).
• National Programme “Ramón y Cajal”. Programme for the employment of doctors by Research and Development centres (RYC-2015-17205. “Precision medicine of allergic diseases: genetic susceptibility and treatment response”). PI: María del Mar del Pino Yanes. MINECO (Ramón y Cajal Sub-programme 2016-2021, 268,600 € -salary, 5 years + 40,000 €, research project)

PUBLICATIONS 2019:

• Daya M, Rafaels N, Brunetti TM, Chavan S, Levin AM, Shetty A, Gignoux CR, Boorgula MP, Wojcik G, Campbell M, Vergara C, Torgerson DG, Ortega VE, Doumatey A, Johnston HR, Acevedo N, Araujo MI, Avila PC, Belbin G, Bleecker E, Bustamante C, Caraballo L, Cruz A, Dunston GM, Eng C, Faruque MU, Ferguson TS, Figueiredo C, Ford JG, Gan W, Gourraud PA, Hansel NN, Hernandez RD, Herrera-Paz EF, Jiménez S, Kenny EE, Knight-Madden J, Kumar R, Lange LA, Lange EM, Lizee A, Maul P, Maul T, Mayorga A, Meyers D, Nicolae DL, O’Connor TD, Oliveira RR, Olopade CO, Olopade O, Qin ZS, Rotimi C, Vince N, Watson H, Wilks RJ, Wilson JG, Salzberg S, Ober C, Burchard EG, Williams LK, Beaty TH, Taub MA, Ruczinski I, CAAPA consortium (including Maria Pino-Yanes), Mathias RA, Barnes KC; CAAPA. Association study in African-admixed populations across the Americas recapitulates asthma risk loci in non-African populations. Nat Commun. 2019 Feb 20;10(1):880. doi: 10.1038/s41467-019-08469-7.
• Spear ML Hu D, Pino-Yanes M, Huntsman S, Eng C, Levin AM, Ortega VE, White MJ, McGarry ME, Thakur N, Galanter J, Mak ACY, Oh SS, Ampleford E, Peters SP, Davis A, Kumar R, Farber HJ, Meade K, Avila PC, Serebrisky D, Lenoir MA, Brigino- Buenaventura E, Cintron WR, Thyne SM, Rodriguez-Santana JR, Ford JG, Chapela R, Estrada AM, Sandoval K, Seibold MA, Winkler CA, Bleecker ER, Myers DA, Williams LK, Hernandez RD, Torgerson DG, Burchard EG. A genome-wide association and admixture mapping study of bronchodilator drug response in African Americans with asthma. Pharmacogenomics J. 2019 Jun;19(3):249-259. doi: 10.1038/s41397-018-0042-4
• Hernandez-Pacheco N, Farzan N, Francis B, Karimi L, Repnik K, Vijverberg SJ, Soares P, Schieck M, Gorenjak M, Forno E, Eng C, Oh SS, Pérez-Méndez L, Berce V, Tavendale R, Samedy LA, Hunstman S, Hu D, Meade K, Farber HJ, Avila PC, Serebrisky D, Thyne SM, Brigino-Buenaventura E, Rodriguez-Cintron W, Sen S, Kumar R, Lenoir M, Rodriguez-Santana JR, Celedón JC, Mukhopadhyay S, Potočnik U, Pirmohamed M, Verhamme KM, Kabesch M, Palmer CNA, Hawcutt DB, Flores C, Maitland-van der Zee AH, Burchard EG, Pino-Yanes M. Genome-wide association study of inhaled corticosteroid response in admixed children with asthma. Clin Exp Allergy. 2019 Jun;49(6):789-798. doi: 10.1111/cea.13354
• Levin AM, Gui H, Hernandez-Pacheco N, Yang M, Xiao S, Yang JJ, Hochstadt S, Barczak AJ, Eckalbar WL, Rynkowski D, Samedy LA, Kwok PY, Pino-Yanes M, Erle DJ, Lanfear DE, Burchard EG, Williams LK. Integrative approach identifies corticosteroid response variant in diverse populations with asthma. J Allergy Clin Immunol. 2019 May;143(5):1791-1802. doi: 10.1016/j.jaci.2018.09.034
• Almoguera B, Vazquez L, Mentch F, March ME, Connolly JJ, Peissig PL, Linneman JG, Plaza-Serón MDC, Pino-Yanes M, Burchard EG, Brilliant M, Sleiman P, Hakonarson H. Novel locus for atopic dermatitis in African Americans and replication in European Americans. J Allergy Clin Immunol. 2019 Mar;143(3):1229-1231. doi: 10.1016/j.jaci.2018.10.038
• Gignoux CR, Torgerson DG, Pino-Yanes M, Uricchio LH, Galanter J, Roth LA, Eng C, Hu D, Nguyen EA, Huntsman S, Mathias RA, Kumar R, Rodriguez-Santana J, Thakur N, Oh SS, McGarry M, Moreno-Estrada A, Sandoval K, Winkler CA, Seibold MA, Padhukasahasram B, Conti DV, Farber HJ, Avila P, Brigino-Buenaventura E, Lenoir M, Meade K, Serebrisky D, Borrell LN, Rodriguez-Cintron W, Thyne S, Joubert BR, Romieu I, Levin AM, Sienra-Monge JJ, Del Rio-Navarro BE, Gan W, Raby BA, Weiss ST, Bleecker E, Meyers DA, Martinez FJ, Gauderman WJ, Gilliland F, London SJ, Bustamante CD, Nicolae DL, Ober C, Sen S, Barnes K, Williams LK, Hernandez RD, Burchard EG. An admixture mapping meta-analysis implicates genetic variation at 18q21 with asthma susceptibility in Latinos. J Allergy Clin Immunol. 2019 Mar;143(3):957-969. doi: 10.1016/j.jaci.2016.08.057
• Hernandez-Pacheco N, Pino-Yanes M, Flores C. Genomic Predictors of Asthma Phenotypes and Treatment Response. Front Pediatr. 2019 Feb 5;7:6. doi: 10.3389/fped.2019.00006
• Herrera-Luis E, Hernandez-Pacheco N, Vijverberg SJ, Flores C, Pino-Yanes M. Role of genomics in asthma exacerbations. 2019 Current Opinion in Pulmonary Medicine 25(1), pp. 101-112. doi: 10.1097/MCP.0000000000000533
• Lona-Durazo F, Hernandez-Pacheco N, Fan S, Zhang T, Choi J, Kovacs MA, Loftus SK, Le P, Edwards M, Fortes-Lima CA, Eng C, Huntsman S, Hu D, Gómez-Cabezas EJ, Marín-Padrón LC, Grauholm J, Mors O, Burchard EG, Norton HL, Pavan WJ, Brown KM, Tishkoff S, Pino-Yanes M, Beleza S, Marcheco-Teruel B, Parra EJ. Meta-analysis of GWA studies provides new insights on the genetic architecture of skin pigmentation in recently admixed populations. BMC Genet. 2019 Jul 17;20(1):59. doi: 10.1186/s12863-019-0765-5
• Espuela-Ortiz A, Lorenzo-Diaz F, Baez-Ortega A, Eng C, Hernandez-Pacheco N, Oh SS, Lenoir M, Burchard EG, Flores C, Pino-Yanes M. Bacterial salivary microbiome associates with asthma among african american children and young adults. Pediatr Pulmonol. 2019 Dec;54(12):1948-1956. doi: 10.1002/ppul.24504
• Dijk FN, Vijverberg SJ, Hernandez-Pacheco N, Repnik K, Karimi L, Mitratza M, Farzan N, Nawijn MC, Burchard EG, Engelkes M, Verhamme KM, Potočnik U, Pino-Yanes M, Postma DS, Maitland-van der Zee AH, Koppelman GH. IL1RL1 gene variations are associated with asthma exacerbations in children and adolescents using inhaled corticosteroids. Allergy. 2019 Nov 22. doi: 10.1111/all.14125. [Epub ahead of print]
• Samedy-Bates LA, Oh SS, Nuckton TJ, Elhawary JR, White M, Elliot T, Zeiger AM, Eng C, Salazar S, LeNoir MA, Meade K, Farber HJ, Serebrisky D, Brigino-Buenaventura E, Rodriguez-Cintron W, Bibbins-Domingo K, Kumar R, Thyne S, Borrell LN, Rodriguez- Santana JR, Pino-Yanes M, Burchard EG. Racial/ethnic-specific differences in the effects of inhaled corticosteroid use on bronchodilator response in patients with asthma. Clin Pharmacol Ther. 2019 Nov;106(5):1133-1140. doi: 10.1002/cpt.1555

OTHER SELECTED PUBLICATIONS FROM THE LAST 10 YEARS:

• Hernandez-Pacheco N, Flores C, Alonso S, Eng C, Mak AC, Hunstman S, Hu D, White MJ, Oh SS, Meade K, Farber HJ, Avila PC, Serebrisky D, Thyne SM, Brigino-Buenaventura E, Rodriguez-Cintron W, Sen S, Kumar R, Lenoir M, Rodriguez-Santana JR, Burchard EG, Pino-Yanes M. Identification of a novel locus associated with skin colour in African-admixed populations. Sci Rep 2017;7:44548. doi: 10.1038/srep44548
• Pino-Yanes M, Thakur N, Gignoux CR, Galanter JM, Roth LA, et al. Genetic ancestry influences asthma susceptibility and lung function among Latinos. J Allergy Clin Immunol. 2015 Jan;135(1):228-35. doi: 10.1016/j.jaci.2014.07.053
• Pino-Yanes M, Gignoux CR, Galanter JM, Levin AM, Campbell CD, Eng C, Huntsman S, Nishimura KK, Gourraud PA, Mohajeri K, O’Roak BJ, Hu D, Mathias RA, Nguyen EA, Roth LA, Padhukasahasram B, Moreno-Estrada A, Sandoval K, Winkler CA, Lurmann F, Davis A, Farber HJ, Meade K, Avila PC, Serebrisky D, Chapela R, Ford JG, Lenoir MA, Thyne SM, Brigino-Buenaventura E, Borrell LN, Rodriguez-Cintron W, Sen S, Kumar R, Rodriguez-Santana JR, Bustamante CD, Martinez FD, Raby BA, Weiss ST, Nicolae DL, Ober C, Meyers DA, Bleecker ER, Mack SJ, Hernandez RD, Eichler EE, Barnes KC, Williams LK, Torgerson DG, Burchard EG. Genome-wide association study and admixture mapping reveal new loci associated with total IgE levels in Latinos. J Allergy Clin Immunol. 2015 Jun;135(6):1502-10. doi: 10.1016/j.jaci.2014.10.033
• Igartua C, Myers RA, Mathias RA, Pino-Yanes M, Eng C, Graves PE, Levin AM, Del-Rio-Navarro BE, Jackson DJ, Livne OE, Rafaels N, Edlund CK, Yang JJ, Huntsman S, Salam MT, Romieu I, Mourad R, Gern JE, Lemanske RF, Wyss A, Hoppin JA, Barnes KC, Burchard EG, Gauderman WJ, Martinez FD, Raby BA, Weiss ST, Williams LK, London SJ, Gilliland FD, Nicolae DL, Ober C. Ethnic-specific associations of rare and low-frequency DNA sequence variants with asthma. Nat Commun. 2015 Jan 16;6:5965. doi: 10.1038/ncomms6965
• Pino-Yanes M, Corrales A, Acosta-Herrera M, Pérez-Rodríguez E, Cumplido J, Campo P, Barreto-Luis A, Sánchez-García F, Felipe T, Sánchez-Machín I, Quintela I, García-Robaina JC, Villar J, Blanca M, Carracedo A, Carrillo T, Flores C. HLA-DRB1*15:01 allele protects from asthma susceptibility. J Allergy Clin Immunol. 2014 Nov;134(5):1201-3. doi: 10.1016/j.jaci.2014.05.031