INVESTIGADORES RESPONSABLES

COLLABORATORS AND CLINICAL RESEARCHERS:

• David Nicolás Pérez, MD, PhD (Head of the Endoscopy Section, HUC)
• Laura Ramos, MD, PhD (Attending Physician, HUC)
• Marta Carrillo Palau, MD, PhD (Attending Physician, HUC)
• Inmaculada Alonso Abreu, MD, PhD (Attending Physician, HUC)
• Zaida Adrián de Ganzo, MD, PhD (Attending Physician, HUC)
• Yanira González Méndez, MD, PhD (Attending Physician, HUC)
• Goretti Hernández Mesa, MD (HUC)
• Onofre Alarcón Fernández, MD (HUC)
• Noemi Hernández Bouilla, MD (HUC)
• Eduardo Rodríguez Hernández, MD (HUC)
• Dalia Elena Morales Arráez, MD (HUC)
• Carlos González Alayón, MD (HUC)
• Cristina Reygosa (MIR, HUC)
• Alberto Hernández Bustabad (MIR, HUC)
• Francisco Javier Pérez Hernández (MIR, Communityand Family Medicine)
• Natalia González López (D.U.E., HUC)

PHD STUDENTS AND TRAINEES:

• Carlos González Alayón, (PhD student, MD, HUC)
• Natalia González López (PhD student, DUE, HUC)
• Cristina Reygosa (Alumna de Doctorado, MIR, HUC)

TECHNICAL AND ADMINISTRATIVE STAFF:

• José Luis Baute Dorta (DUE, HUC)
• Beatriz Pérez Abrante (Laboratory technician in Experimental techniques, HUC)
• Eladio Frías Arrocha (Data Manager)

RESEARCH LINES:

• Gastrointestinal cancer prognostic factors and prevention strategies (“Factores pronósticos y estrategias para la prevención del cáncer gastrointestinal”).
• Physiopathology of portal hypertension and new treatments (“Fisiopatología de la hipertensión portal y nuevos tratamientos”).
• Immunogenicity and vaccine response of hepatic disease patients (“Inmunogenicidad y respuesta a vacunas en pacientes con enfermedad hepática”).
• New functional markers of cirrhosis and ascite physiopathology, and markers of non-alcoholic steatohepatitis (“Nuevos marcadores de función renal en el cirrótico y fisiopatología de la ascitis, así como marcadores de esteatohepatitis no alcohólica”).
• Pathogenic factors and new treatments for Chronic Inflammatory Disease (“Factores patogénicos y nuevos tratamientos en la Enfermedad Inflamatoria Crónica”).
• Projects for the micro-elimination of hepatitis C virus (“Proyectos de microeliminación del virus de la hepatitis C”).

FUNDED PROJECTS:

• Identification of new biomarkers for the prevention of colorectal cancer (“Identificación de nuevos biomarcadores para la prevención del cáncer colorrectal”). PI: Enrique Quintero. Spanish Association against Cancer (2013-2019, 183,896 €).
• Immunological faecal blood test to diagnose iron-deficiency anaemia (PI16/02011- “Evaluación del test inmunológico de sangre oculta en heces en el proceso diagnóstico pacientes con anemia ferropénica”). PI: Enrique Quintero. Heath Institute Carlos III (2017-2019, 57,475 €).
• Improvement of clinical practice management and/or of training within the Foundation, to benefit and improve patient care (“Mejora de la gestión de la práctica clínica y/o, formación dentro de la Fundación, al objeto de beneficiar y mejorar la práctica de la medicina en los pacientes”). PI: Enrique Quintero. ABBVIE (2018, 40,000 €)
• Comparison fecal occult blood test and colonoscopy in familial colorectal cancer screening: adherence, diagnostic yield and cost-effectiveness (PI15/01257). PI: Antonio Z. Gimeno. Institute of Health Carlos III (2016-2019, 110,352 €).

PUBLICATIONS 2019:

• Mangas-Sanjuan C,Jover R,Cubiella J,Marzo-Castillejo M,Balaguer F,Bessa X,Bujanda L, Bustamante M,Castells A, Diaz-Tasende J,Díez-Redondo P,Herráiz M,Mascort-Roca JJ, Pellisé M,Quintero E;Grupo de Cribado del Cáncer Colorrectal de la Sociedad Española de Epidemiología. Endoscopic surveillance after colonic polyps and colorrectal cancer resection. 2018 update [Vigilancia tras resección de pólipos de colon y de cáncer colorrectal. Actualización 2018]. Gastroenterol Hepatol. 2019 Mar;42(3):188-201. doi: 10.1016/j.gastrohep.2018.11.001
• Herreros-Villanueva M,Duran-Sanchon S,Martín AC,Pérez-Palacios R,Vila-Navarro E, Marcuello M,Diaz-Centeno M,Cubiella J,Diez MS,Bujanda L,Lanas A,Jover R, Hernández V,Quintero E,José Lozano J,García-Cougil M,Martínez-Arranz I,Castells A, Gironella M,Arroyo R. Plasma MicroRNA Signature Validation for Early Detection of Colorectal Cancer. Clin Transl Gastroenterol. 2019 Jan;10(1):e00003. doi:10.14309/ctg.0000000000000003
• Gargallo CJ,Lanas Á,Carrera-Lasfuentes P,Ferrandez Á,Quintero E,Carrillo M,Alonso-Abreu I,García-Gonzalez MA.Genetic susceptibility in the development of colorectal adenomas according to family history of colorectal cancer. Int J Cancer. 2019 Feb 1;144(3):489-502. doi: 10.1002/ijc.31858
• Rodríguez-Alcalde D,Carballal S,Moreira L, Hernández L,Rodríguez-Alonso L, Rodríguez-Moranta F,Gonzalo V,Bujanda L,Bessa X, Poves C,Cubiella J,Castro I, González M,Moya E,Oquiñena S, Clofent J,Quintero E,Esteban P,Piñol V,Fernández FJ,Jover R, Cid L, Saperas E,López-Cerón M,Cuatrecasas M,López-Vicente J,Rivero-Sánchez L,Jung G,Vila-Casadesús M,Sánchez A,Castells A,Pellisé M,Balaguer F;Gastrointestinal Oncology Group of the Spanish Gastroenterological Association. High incidence of advanced colorectal neoplasia during endoscopic surveillance in serrated polyposis syndrome. 2019 Feb;51(2):142-151. doi:10.1055/a-0656-5557
• Morales-Arraez D, Alonso-Larruga A, Diaz-Flores F, García Dopico JA, de Vera A, Quintero E, Hernández-Guerra M. Predictive factors for not undergoing RNA testing in patients found to have hepatitis C serology and impact of an automatic alert. Journal of Viral Hepatitis. 2019 Sep;26(9):1117-1123. doi: 10.1111/jvh.13122
• Morales-Arraez D, Hernandez-Guerra M, Diaz-Flores F, Nieto-Bujalance Y, Garcia- Dopico J, Jimenez A, Quintero E. Hepatitis C virus media coverage favorably impacts on antibody testing in the non-interferon era. J Public Health (Oxf). 2019 Nov 30. pii:fdz149. doi: 10.1093/pubmed/fdz14 [Epub ahead of print]
• Gómez L, Reygosa C, Morales-Arráez DE, Ramos R, Pérez A, Hernández A, Quintero E, Gutiérrez F, Diaz-Flores F, Hernández-Guerra M. Diagnostic test accuracy of the cobas 6800 system for detection of hepatitis c virus viraemia levels from dried blood spots. Enferm Infecc Microbiol Clin. 2019 Dec 4. pii: S0213-005X(19)30300-3. doi: 10.1016/j.eimc.2019.10.009 [Epub ahead of print]
• Morales-Arraez D, Nieto Bujalance Y, Diaz-Flores F, de Vera A, Jiménez A, Garcia Dopico JA, Quintero E, Hernández-Guerra M. Risk of liver fibrosis progression inpatients with suboptimal diagnosis of hepatitis C virus infection. Eur J Gastroenterol Hepatol. 2019 Sep 3. doi: 10.1097/MEG.0000000000001534. [Epub ahead of print]
• Morales-Arraez D, Diaz-Flores F, Alonso A, de Vera A, Jimenez A, Garcia Dopico JA, Quintero E, Hernández-Guerra M. Patients with suboptimal hepatitis B virusdiagnostic characterization are at risk of liver fibrosis progression. Eur J Gastroenterol Hepatol. 2019 Sep 3. doi: 10.1097/MEG.0000000000001527. [Epub ahead of print]
• Hernández G, Gimeno-García AZ, Quintero E. Strategies to optimise the quality of bowel cleansing [Estrategias para optimizar la calidad de la limpieza colónica]. Gastroenterol Hepatol. 2019 May;42(5):326-338. doi: 10.1016/j.gastrohep.2019.01.010
• Hernández G, Gimeno-García AZ, Quintero E. Strategies to Improve Inadequate Bowel Preparation for Colonoscopy. Front Med (Lausanne). 2019 Nov 8;6:245. doi: 10.3389/fmed.2019.00245
• Gimeno-García AZ,de la Barreda Heuser R, Reygosa C,Hernandez A,Mascareño I, Nicolás-Pérez D,Jiménez A,Lara AJ,Alarcon-Fernández O,Hernandez-Guerra M, Romero R,Alonso I,González Y,Adrian Z,Hernandez G,Hernandez D,DelgadoR, Quintero E. Impact of a 1-day versus 3-day low-residue diet on bowel cleansing quality before colonoscopy:A randomized controlled trial. 2019 Jul;51(7):628-636. doi: 10.1055/a-0864-1942
• Hernández-Guerra M, Hadjihambi A, Jalan R. Gap junctions in liver disease: Implications for pathogenesis and therapy. J Hepatol. 2019 Apr;70(4):759-772. doi:10.1016/j.jhep.2018.12.023
• Luis-Lima S,Escamilla-Cabrera B,Negrín-Mena N,Estupiñán S,Delgado-Mallén P,Marrero-Miranda D,González-Rinne A, Miquel-Rodríguez R,Cobo-CasoMÁ,Hernández-Guerra M, Oramas J,Batista N,Aldea-Perona A,Jorge-Pérez P,González-Alayón C,Moreno-Sanfiel M,González-Rodríguez JA,Henríquez L,Alonso-Pescoso R,Díaz-Martín L, González-Rinne F,Lavín-Gómez BA, Galindo-Hernández J, Sánchez-Gallego M,González-Delgado A,Jiménez-Sosa A,Torres A,Porrini E. Chronic kidney disease staging with cystatin C or creatinine-based formulas: Flipping the coin. Nephrol Dial Transplant. 2019 Feb 1;34(2):287-294. doi: 10.1093/ndt/gfy086
• Llaneras J,Riveiro-Barciela M,Lens S,Diago M,Cachero A,García-Samaniego J,Conde I, Arencibia A,Arenas J,Gea F,Torras X,Luis Calleja J,Antonio Carrión J,Fernández I, María Morillas R,Rosales JM,Carmona I,Fernández-Rodríguez C,Hernández-GuerraM, Llerena S,Bernal V,Turnes J,González-Santiago JM,Montoliu S,Figueruela B,Badia E, Delgado M,Fernández-Bermejo M,Iñarrairaegui M,Pascasio JM,Esteban R,Mariño Z, Buti M. Effectiveness and safety of sofosbuvir/velpatasvir/voxilaprevir in patients with chronic hepatitis C previously treated with DAAs. J Hepatol. 2019 Oct;71(4):666-672. doi: 10.1016/j.jhep.2019.06.002
• Fernández Rodríguez CM,Aller R, Gutiérrez García ML,Ampuero J,Gómez-Camarero J, Martín-Mateos RMª, Burgos-Santamaría D,Rosales JM,Aspichueta P,Buque X, Latorre M,Andrade RJ,Hernández-Guerra M,Romero-Gómez M. Higher levels of serum uric acid influences hepatic damage in patients with non-alcoholic fatty liver disease (NAFLD). Rev Esp Enferm Dig. 2019 Apr;111(4):264-269. doi:10.17235/reed.2019.5965/2018
• Crespo J, Albillos A, Buti M, Calleja JL, García-Samaniego J, Hernández-Guerra M, Serrano T, Turnes J, Acín E, Berenguer J, Berenguer M, Colom J, Fernández I, Fernández Rodríguez C, Forns X, García F, Granados R, Lazarus J, Molero JM, Molina E, Pérez Escanilla F, Pineda JA, Rodríguez M, Romero M, Roncero C, Saiz de la Hoya P, Sánchez Antolín G. Elimination of hepatitis C. Positioning document of the Spanish Association for the Study of the Liver (AEEH). Gastroenterol Hepatol. 2019 Nov;42(9):579-592. doi:10.1016/j.gastrohep.2019.09.002
• Hernández-Gea V,Procopet B,Giráldez Á,Amitrano L,Villanueva C,Thabut D,Ibañez-Samaniego L,Silva-Junior G,Martinez J,Genescà J,Bureau C,Trebicka J,Llop E, Laleman W,Palazon JM,Castellote J,Rodrigues S,Gluud LL,Noronha Ferreira C, Barcelo R,Cañete N,Rodríguez M,Ferlitsch A,Mundi JL,Gronbaek H, Hernández-Guerra M,Sassatelli R,Dell’Era A,Senzolo M,Abraldes JG,Romero-Gómez M,Zipprich A, Casas M, Masnou H,Primignani M,Krag A,Nevens F,Calleja JL,Jansen C,RobicMA,Conejo I,Catalina MV,Albillos A,Rudler M,Alvarado E,Guardascione MA,Tantau M,Bosch J, Torres F,Garcia-Pagán JC;International Variceal Bleeding Observational Study Group and Baveno Cooperation. Preemptive-TIPS Improves Outcome in High-Risk Variceal Bleeding: An Observational Study. 2019 Jan;69(1):282-293. doi: 10.1002/hep.30182
• Crespo J, Albillos A, Buti M, Calleja JL, García-Samaniego J, Hernández-Guerra M, Serrano T, Turnes J, Acín E, Berenguer J, Berenguer M, Colom J, Fernández I, Fernández Rodríguez C, Forns X, García F, Granados R, Lazarus J, Molero JM, Molina E, Pérez Escanilla F, Pineda JA, Rodríguez M, Romero M, Roncero C, Saiz de la Hoya P, Sánchez Antolín G. Elimination of hepatitis C. Positioning document of the Spanish Association for the Study of the Liver (AEEH). Rev Esp Enferm Dig. 2019 Nov;111(11):862-873. doi: 10.17235/reed.2019.6700/2019
• Bataller R, Cabezas J, Aller R, Ventura-Cots M, Abad J, Albillos A, Altamirano J, Arias-Loste MT, Bañares R, Caballería J, Caballería L, Carrión JA, Diago M, Fernández Rodríguez C, Gallego R, García-Cortes M, García-Monzón C, Genescà J, Ginés P, Hernandez-Guerra M, Jorquera F, Lligoña A, Molina E, Pareja MJ, Planas R, Tomé S, Salmerón J, Romero-Gómez M. Alcohol-related liver disease. Clinical practice guidelines. Consensus document sponsored by AEEH. Gastroenterol Hepatol. 2019 Dec;42(10):657-676. doi: 10.1016/j.gastrohep.2019.09.006
• Manuel Sousa J, Vergara M, Pulido F, Sánchez Antolín G, Hijona L, Carnicer F, Rincón D, Salmerón J, Mateos-Muñoz B, Jou A, Polo-Lorduy B, Rubín Á, Escarda A, Aguilar P, Aldámiz-Echevarría T, García-Buey L, Carrión JA, Hernández-Guerra M, Chimeno-Hernández S, Espinosa N, Morillas RM, Andrade RJ, Delgado M, Gallego A, Magaz M, Moreno-Planas JM, Estébanez Á, Rico M, Menéndez F, Sampedro B, Morano L, Izquierdo S, Zozaya JM, Rodríguez M, Morán-Sánchez S, Lorente S, Martín-Granizo I, Von-Wichmann MÁ, Delgado M, Manzanares A. Real-world evidence of the effectiveness of ombitasvir-paritaprevir/r ± dasabuvir ± ribavirin in patients monoinfected with chronic hepatitis C or coinfected with human immunodeficiency virus-1 in Spain. PLoS One. 2019 Nov 12;14(11):e0225061. doi: 10.1371/journal.pone.0225061
• Orive M,Aguirre U,Gonzalez N,Lázaro S,Redondo M,Bare M,Anula R,Briones E, Escobar A,Sarasqueta C, Garcia-Gutierrez S,Quintana JM;REDISSEC-CARESS/CCRgroup (Gimeno-Garcia AZ). Risk factors affecting hospital stay among patients undergoing colon cancer surgery: a prospective cohort study. Support Care Cancer. 2019 Nov;27(11):4133-4144. doi: 10.1007/s00520-019-04683-7
• Téllez T,Abitei C,Padilla-Ruiz MDC,Rivas-Ruiz F,Fúnez R,Pereda T,Rodrigo I,Alcaide J, Baré ML,Morales Suárez-Varela MM,Zabalza I,Sánchez Del Charco M,Borrero Martín JJ,García Del Moral R,Escobar A,Quintana JM,Aguirre U,Redondo M;REDISSEC-CARESS/CCR group (Gimeno-Garcia AZ). Biological and prognostic differences between symptomatic colorectal carcinomas and those detected by screening. Eur J Surg Oncol. 2019 Oct;45(10):1876-1881. doi: 10.1016/j.ejso.2019.05.027
• Martin-Cardona A,Fernandez-Esparrach G,Subtil JC,Iglesias-Garcia J,Garcia-Guix M,Barturen Barroso A,Gimeno-Garcia AZ,Esteban JM,Pardo Balteiro A,Velasco-Guardado A,Vazquez-Sequeiros E,Loras C,Martinez-Moreno B,Castellot A,Huertas C, Martinez-Lapiedra M,Sanchez-Yague A,Teran A,Morales-Alvarado VJ,Betes M,de la Iglesia D,Sánchez-Montes C,Lozano MD,Lariño-Noia J,Gines A,Tebe C,Gornals JB;On belhaf of Spanish Group for EUS-Guided TA in the adrenal gland. EUS-guided tissue acquisition in the study of the adrenal glands: Results of a nationwide multicenter study. PLoS One. 2019 Jun 6;14(6):e0216658. doi: 10.1371/journal.pone.0216658
• Puig I,López-Cerón M,Arnau A,Rosiñol Ò, Cuatrecasas M,Herreros-de-Tejada A, Ferrández Á,Serra-Burriel M,Nogales Ó,Vida F, de Castro L,López-Vicente J,VegaP,Álvarez-González MA,González-Santiago J,Hernández-Conde M,Díez-RedondoP,Rivero-Sánchez L,Gimeno-García AZ,Burgos A,García-Alonso FJ,Bustamante-Balén M,Martínez-Bauer E,Peñas B,Pellise M;EndoCAR group, Spanish Gastroenterological Association and the Spanish Digestive Endoscopy Society. Accuracy of the Narrow-Band Imaging International Colorectal Endoscopic Classification System in Identification of DeepInvasion in Colorectal Polyps. 2019 Jan;156(1):75-87. doi: 10.1053/j.gastro.2018.10.004
• Albéniz E, Gimeno-García AZ, Fraile M, Ibáñez B, Guarner-Argente C, Alonso-Aguirre P, Álvarez MA, Gargallo CJ, Pellisé M, Ramos Zabala F, Herreros de Tejada A, Nogales Ó, Martínez-Ares D, Múgica F, de la Peña J, Espinós J, Huerta A, Álvarez A, Gonzalez-Santiago JM, Navajas F, Martínez-Cara JG, Redondo-Cerezo E, Merlo Mas J, Sábado F, Rivero L, Saperas E, Soto S, Rodríguez-Sánchez J, López-Roses L, Rodríguez-Téllez M, Rullán Iriarte M, Elosua González A, Pardeiro R, Valdivielso Cortázar E, Concepción-Martín M, Huelin Álvarez P, Colán Hernández J, Cobian J, Santiago J, Jiménez A, Remedios D, López-Viedma B, García O, Martínez-Alcalá F, Pérez-Roldán F, Carbó J, Enguita M. Clinical validation of risk scoring systems to predict risk of delayed bleeding after EMR of large colorectal lesions. Gastrointest Endosc. 2019 Oct 23. pii: S0016-5107(19)32382-X. doi: 10.1016/j.gie.2019.10.013 [Epub ahead of print]

OTHER SELECTED PUBLICATIONS FROM THE LAST 10 YEARS:

• Quintero E, Castells A, Bujanda L. et al. Colonoscopy versus fecal immunochemical testing in colorectal-cancer screening. N Engl J Med. 2012 Feb 23;366(8):697-706. doi:10.1056/NEJMoa1108895
• Quintero E, Carrillo M, Leoz ML, Cubiella J, Gargallo C, Lanas A, Bujanda L, Gimeno-García AZ, Hernández-Guerra M, Nicolas-Perez D, Alonso-Abreu I, Morillas JD, Balaguer F, Muriel A; Oncology Group of the Asociacion Española de Gastroenterología (AEG). Risk of Advanced Neoplasia in First-Degree Relatives with Colorectal Cancer: A Large Multicenter Cross-Sectional Study. PLoS Medicine 2016 May 3;13(5):e1002008. doi: 10.1371/journal.pmed.1002008
• Jover R, Zapater P, Bujanda L, Hernandez V, Cubiella J, Pellise M, Ponce M,Ono A, Lanas A, Seoane A, Marin-Gabriel JC, Chaparro M, Cacho G, Herreros-de-Tejada A, Fernandez-Diez S, Peris A, Nicolas-Perez D, Murcia O, Castells A, Quintero E; COLONPREV Study Investigators. Endoscopist characteristics that influence the quality of colonoscopy. Endoscopy 2016 Mar;48(3):241-7. doi: 10.1055/s-0042-100185
• Castells A, Bessa X, Quintero E, et al. Risk of Advanced Proximal Neoplasms According to Distal Colorectal Findings: Comparison of Sigmoidoscopy-Based Strategies. J Natl Cancer Inst. 2013 Jun 19;105(12):878-886
• Quintero E,Carrillo M,Gimeno-García AZ,Hernández-Guerra M,Nicolás-PérezD,Alonso-Abreu I,Díez-Fuentes ML,Abraira V. Equivalency of Fecal Immunochemical Tests and Colonoscopy in Familial Colorectal Cancer Screening. 2014 Nov;147(5):1021-30.e1; quiz e16-7. doi: 10.1053/j.gastro.2014.08.004
• Abraldes JG,Villanueva C, Aracil C,Turnes J,Hernandez-Guerra M,Genesca J, Rodriguez M,Castellote J,García-Pagán JC,Torres F,Calleja JL,Albillos A,BoschJ; BLEPS Study Group.Addition of Simvastatin to Standard Therapy for the Prevention of Variceal Rebleeding Does Not Reduce Rebleeding but Increases Survival in Patients with Cirrhosis. Gastroenterology. 2016 May; 150(5): 1160-1170. doi: 10.1053/j.gastro.2016.01.004
• Hernández-Guerra M, de Ganzo ZA, Gonzalez-Mendez Y, Salido E, Abreu P, Moreno M, Felipe V, Abrante B, Quintero E. Chronic intermittent hypoxia aggravates intrahepatic endothelial dysfunction in cirrhotic rats. 2013 Apr;57(4):1564-74. doi: 10.1002/hep.26152