PRINCIPAL INVESTIGATOR

POSTDOCTORAL RESEARCHERS:

• Guadalberto Hernández Hernández, MD, PhD (Professor of Physiology, Department of Basic Medical Sciences, ULL)
• Silvia Velázquez García, PhD (Agustín de Betancourt Researcher, ULL)

PHD STUDENTS AND TRAINEES:

• Brian Almeida Prieto (FPI, MINECO, BES-2017-082939, associated to project BFU2016-78374-R)
• Arianna Vastola Mascolo (MICINN, BFU2016-78374-R)

RESEARCH LINES:

In the laboratory we study the mechanisms of action of adrenal mineralocorticoids and glucocorticoids through the following research lines:

• Identification and analysis of the physiological target genes of aldosterone and glucocorticoid. The main objective of this research is to improve our understanding of cellular and molecular glucocorticoid hormone signalling under physiological conditions, and in association with different pathologies: hypertension, kidney and vascular damage, metabolic syndrome. To this end, we aim to develop relevant animal models for these pathologies and identify new therapeutic targets.
• The study of the cellular biology and molecular mechanisms involved in mineralocorticoid receptor activation, with a view to identify the cellular processes and structural features involved in aldosterone and glucocorticoid signal transduction.

FUNDED PROJECTS:

• Altered mineralocorticoid receptor activation: mechanisms and physiopathology (INMIR, BFU2016-78374-R – “Activación inapropiada del receptor de mineralocorticoides: fisiopatología y Mecanismos”). PI: Diego Álvarez de la Rosa. Ministry of Economy and Competitiveness, MINECO (2017-2019, 200,000 €)
• MetSPLAT: An in vivo platform for metabolic syndrome preclinical drug tests. Agustín de Betancourt Project. PI: Silvia Velázquez García; Tutor: Diego Álvarez de la Rosa. Regional Government of Tenerife (2017-2021, 160,000 €)

PUBLICATIONS 2019:

• Knoepp F, Ashley Z, Barth D, Baldin JP, Jennings M, Kazantseva M, Saw EL, Katare R, Alvarez de la Rosa D, Weissmann N, Fronius M. Shear force sensing of epithelial Na+ channel (ENaC) relies on N-glycosylated asparagines in the palm and knuckle domains of αENaC. Proc Natl Acad Sci USA. 2020 Jan 7;117(1):717-726. doi: 10.1073/pnas.1911243117. Epub 2019 Dec 23
• Armas-Capote N, Maglio LE, Pérez-Atencio L, Martin-Batista E, Reboreda A, Barios JA, Hernandez G, Alvarez de la Rosa D, Lamas JA, Barrio LC, Giraldez T. SGK1.1 Reduces Kainic Acid-Induced Seizure Severity and Leads to Rapid Termination of Seizures. Cereb Cortex. 2019 Dec 9. pii: bhz302. doi: 10.1093/cercor/bhz302
• Butterworth MB, Alvarez de la Rosa D. Regulation of Aldosterone Signaling by MicroRNAs. Vitam Horm. 2019;109:69-103. doi: 10.1016/bs.vh.2018.09.002
• Herrera JL, Ordoñez-Gutierrez L, Fabrias G, Casas J, Morales A, Hernandez G, Acosta NG, Rodriguez C, Prieto-Valiente L, Garcia-Segura LM, Wandosell FG, Alonso R. Ovarian Hormone-Dependent Effects of Dietary Lipids on APP/PS1 Mouse Brain. Front Aging Neurosci. 2019 Dec 19;11:346. doi: 10.3389/fnagi.2019.00346

OTHER SELECTED PUBLICATIONS FROM THE LAST 10 YEARS:

• Jiménez-Canino R, Lorenzo-Díaz F, Odermatt A, Bailey MA, Livingstone DE, Jaisser F, Farman N, Alvarez de la Rosa D. 11β-HSD2 SUMOylation Modulates Cortisol-induced Mineralocorticoid Receptor Nuclear Translocation Independently of Effects on Transactivation. Endocrinology. 2017 Nov 1;158(11):4047-4063. doi: 10.1210/en.2017-00440
• Jiménez-Canino R, Fernandes MX, Alvarez de la Rosa D. Phosphorylation of mineralocorticoid receptor ligand binding domain impairs receptor activation and has a dominant negative effect over non-phosphorylated receptors. J Biol Chem. 2016 Sep 2;291(36):19068-78. doi: 10.1074/jbc.M116.718395
• Jiménez-Canino R, Lorenzo-Diaz F, Jaisser F, Farman N, Giráldez T, Álvarez de la Rosa D. Histone deacetylase 6-controlled Hsp90 acetylation significantly alters mineralocorticoid receptor subcellular dynamics but not its transcriptional activity. Endocrinology. 2016 Jun;157(6):2515-32. doi: 10.1210/en.2015-2055
• Hernandez-Diaz I, Giráldez T, Morales S, Hernández G, Salido E, Canessa CM, Álvarez de la Rosa D. Heterogeneous nuclear ribonucleoprotein A2/B1 is a tissue-specific aldosterone target gene with prominent induction in the rat distal colon. Am J Physiol Gastrointest Liver Physiol. 2013 Jan 15;304(2):G122-31. doi: 10.1152/ajpgi.00130.2012
• Urbanet R, Nguyen Dinh Cat A, Feraco A, Gravez B, El Mograhbi S, Sierra-Ramos C, Alvarez de la Rosa D, Quilliot D, Rossignol P, Venteclef N, Clement K, Fallo F, Touyz RM, Jaisser F. Adipocyte mineralocorticoid receptor activation leads to metabolic syndrome and induction of Prostaglandin D2 Synthase. Hypertension. 2015 Jul;66(1):149-57. doi: 10.1161/HYPERTENSIONAHA.114.04981