This issue, edited by Francisco A. Lomelí, Sophia Emmanouilidou and Juan Ignacio Oliva, is devoted to Contemporary Challenges in Chicanx Literature and Culture, with some incursions into Latinx authors. The reader will find an ample selection of innovative critical analyses and also creative works, a tribute and an addendum essay. Topics like gender studies, music, human rights, border traumas, ideology and culture are offered to show the vitality of the Chicanx polyphonic vision of the US (and by extension of the Occidental world); one capable of transforming centric attitudes and decoding hegemonic positions.